ASTM D7644-2010 液相色谱/串联质谱法测定水中溴敌隆,溴鼠灵,敌鼠和华法林的标准试验方法
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【英文标准名称】:StandardTestMethodforDeterminationofBromadiolone,Brodifacoum,DiphacinoneandWarfarininWaterbyLiquidChromatography/TandemMassSpectrometry(LC/MS/MS)
【原文标准名称】:液相色谱/串联质谱法测定水中溴敌隆,溴鼠灵,敌鼠和华法林的标准试验方法
【标准号】:ASTMD7644-2010
【标准状态】:现行
【国别】:
【发布日期】:2010
【实施或试行日期】:
【发布单位】:美国材料与试验协会(US-ASTM)
【起草单位】:D19.06
【标准类型】:(TestMethod)
【标准水平】:()
【中文主题词】:液相色谱法;质谱测定法;灭鼠剂;水
【英文主题词】:liquidchromatography;massspectrometry;rodenticides;water
【摘要】:ThistestmethodhasbeendevelopedinsupportoftheNationalHomelandSecurityResearchCenter,USEPAbyRegion5ChicagoRegionalLaboratory(CRL).Bromadiolone,brodifacoum,diphacinoneandwarfarinarerodenticidesforcontrollingmice,rats,andotherrodentsthatposeathreattopublichealth,criticalhabitats,nativeplantsandanimals,crops,foodandwatersupplies.Theserodenticidesalsopresenthumanandenvironmentalsafetyconcerns.Warfarinanddiphacinonearefirst-generationanticoagulants,whilebromadioloneandbrodifacoumaresecond-generation.Theanticoagulantsinterferewithbloodclotting,anddeathcanresultfromexcessivebleeding.Thesecond-generationanticoagulantsareespeciallyhazardousforseveralreasons.Theyarehighlytoxicandpersistalongtimeinbodytissues.Thesecond-generationanticoagulantsaredesignedtobetoxicinasinglefeeding,buttime-to-deathoccursinseveraldays.Thisallowsrodentstofeedmultipletimesbeforedeath,leadingtocarcassescontainingresiduesthatmaybemanytimesthelethaldose.Thismethodhasbeeninvestigatedforusewithreagent,surface,anddrinkingwaterfortheselectedrodenticides.1.1Thisprocedurecoversthedeterminationofbromadiolone,brodifacoum,diphacinoneandwarfarin(referredtocollectivelyasrodenticidesinthistestmethod)inwaterbydirectinjectionusingliquidchromatography(LC)anddetectedwithtandemmassspectrometry(MS/MS).Theseanalytesarequalitativelyandquantitativelydeterminedbythismethod.Thismethodadherestomultiplereactionmonitoring(MRM)massspectrometry.1.2TheDetectionVerificationLevel(DVL)andReportingRangefortherodenticidesarelistedinTable1.1.2.1TheDVLisrequiredtobeataconcentrationatleast3timesbelowtheReportingLimit(RL)andhaveasignal/noiseratiogreaterthan3:1.Fig.1displaysthesignal/noiseratiosoftheprimarysinglereactionmonitoring(SRM)transitions,andFig.2displaystheconfirmatorySRMtransitionsattheDVLsfortherodenticides.1.2.2ThereportinglimitwascalculatedfromtheconcentrationoftheLevel1calibrationstandard,asshowninTable4,accountingforthedilutionofa40mLwatersampleuptoafinalvolumeof50mLwithmethanoltoensureanalytesolubility.1.3Units8212;ThevaluesstatedinSIunitsaretoberegardedasstandard.Nootherunitsofmeasurementareincludedinthisstandard.1.4Thisstandarddoesnotpurporttoaddressallofthesafetyconcerns,ifany,associatedwithitsuse.Itistheresponsibilityoftheuserofthisstandardtoestablishappropriatesafetyandhealthpracticesanddeterminetheapplicabilityofregulatorylimitationspriortouse.
【中国标准分类号】:C51
【国际标准分类号】:13_060_50
【页数】:15P.;A4
【正文语种】:
【原文标准名称】:液相色谱/串联质谱法测定水中溴敌隆,溴鼠灵,敌鼠和华法林的标准试验方法
【标准号】:ASTMD7644-2010
【标准状态】:现行
【国别】:
【发布日期】:2010
【实施或试行日期】:
【发布单位】:美国材料与试验协会(US-ASTM)
【起草单位】:D19.06
【标准类型】:(TestMethod)
【标准水平】:()
【中文主题词】:液相色谱法;质谱测定法;灭鼠剂;水
【英文主题词】:liquidchromatography;massspectrometry;rodenticides;water
【摘要】:ThistestmethodhasbeendevelopedinsupportoftheNationalHomelandSecurityResearchCenter,USEPAbyRegion5ChicagoRegionalLaboratory(CRL).Bromadiolone,brodifacoum,diphacinoneandwarfarinarerodenticidesforcontrollingmice,rats,andotherrodentsthatposeathreattopublichealth,criticalhabitats,nativeplantsandanimals,crops,foodandwatersupplies.Theserodenticidesalsopresenthumanandenvironmentalsafetyconcerns.Warfarinanddiphacinonearefirst-generationanticoagulants,whilebromadioloneandbrodifacoumaresecond-generation.Theanticoagulantsinterferewithbloodclotting,anddeathcanresultfromexcessivebleeding.Thesecond-generationanticoagulantsareespeciallyhazardousforseveralreasons.Theyarehighlytoxicandpersistalongtimeinbodytissues.Thesecond-generationanticoagulantsaredesignedtobetoxicinasinglefeeding,buttime-to-deathoccursinseveraldays.Thisallowsrodentstofeedmultipletimesbeforedeath,leadingtocarcassescontainingresiduesthatmaybemanytimesthelethaldose.Thismethodhasbeeninvestigatedforusewithreagent,surface,anddrinkingwaterfortheselectedrodenticides.1.1Thisprocedurecoversthedeterminationofbromadiolone,brodifacoum,diphacinoneandwarfarin(referredtocollectivelyasrodenticidesinthistestmethod)inwaterbydirectinjectionusingliquidchromatography(LC)anddetectedwithtandemmassspectrometry(MS/MS).Theseanalytesarequalitativelyandquantitativelydeterminedbythismethod.Thismethodadherestomultiplereactionmonitoring(MRM)massspectrometry.1.2TheDetectionVerificationLevel(DVL)andReportingRangefortherodenticidesarelistedinTable1.1.2.1TheDVLisrequiredtobeataconcentrationatleast3timesbelowtheReportingLimit(RL)andhaveasignal/noiseratiogreaterthan3:1.Fig.1displaysthesignal/noiseratiosoftheprimarysinglereactionmonitoring(SRM)transitions,andFig.2displaystheconfirmatorySRMtransitionsattheDVLsfortherodenticides.1.2.2ThereportinglimitwascalculatedfromtheconcentrationoftheLevel1calibrationstandard,asshowninTable4,accountingforthedilutionofa40mLwatersampleuptoafinalvolumeof50mLwithmethanoltoensureanalytesolubility.1.3Units8212;ThevaluesstatedinSIunitsaretoberegardedasstandard.Nootherunitsofmeasurementareincludedinthisstandard.1.4Thisstandarddoesnotpurporttoaddressallofthesafetyconcerns,ifany,associatedwithitsuse.Itistheresponsibilityoftheuserofthisstandardtoestablishappropriatesafetyandhealthpracticesanddeterminetheapplicabilityofregulatorylimitationspriortouse.
【中国标准分类号】:C51
【国际标准分类号】:13_060_50
【页数】:15P.;A4
【正文语种】:
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